Game doens't start anymnore and freezes my PC

After clicking on Start Game, the game guard image comes up... as it would be normally.
After it goes away, nothing happens at first... But then, all windows and even explorer.exe, task manager, don't respond anymore.
Addionally, the window with nothing written pops up (game guard failure)

To close the pc I got to push the main button, wich isn't very good, as you should know.

What can I do?

OS: Vista Sp1
All drivers up-to-date

Tried Admin, compatibility mode XP, deinstalling-reinstalling.

Help?
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