Custom mouse issue?

I have a IntelliMouse Explorer 3 and somehow my two customizable buttons don't work?

I set the custom buttons to r and 3

I have already tried it on some other games and they work fine but in Crossfire only my roller and left and right c******s work -_-

Test: 3r3rrr3r33r3r3r3r3r3r3r3r33r3r3r3r3r3

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